Defending champion John Isner and top-seeded Jo-Wilfried Tsonga had straight-sets victories Thursday night to set up a semifinal match in the Winston-Salem Open. Second-seeded Tomas Berdych and seventh-seeded Sam Querrey also won their quarterfinal matches at the Wake Forest Tennis Complex in the final hard-court tournament before the U.S. Open. Isner had 21 aces in beating David Goffin 7-6 (7-5), 6-3, while the sixth-ranked Tsonga needed only 53 minutes to dispatch sixth-seeded Marcel Granollers 6-1, 6-2.