Vaccine. Jonas Salk is the person behind polio cure. Madaam Curie for radioactivity and her certain death.
Bo Derek was the star of the movie "10." Plus, she's a Republican, so she can replace Indian-killer Andrew Jackson, who had a big production himself when he emptied the South. https://en.wikipedia.org/wiki/Trail_of_Tears
All others pale in comparison as far as their actual positive impact on making America the greatest country in the world. https://en.wikipedia.org/wiki/Mary_Harris_Jones