Politics Trump Owns Stock in Company that produces Hydroxycloroquine

Here is the english translation of the article:

Annalisa Chiusolo, a young pharmacology scholar, sensed the mechanism of action of Sars-Cov-2. By understanding this mechanism, the most effective contrast drugs can be accurately and precisely targeted and selected. Coronavirus would affect the ability of hemoglobin to transport oxygen, creating the underlying assumptions of the impulsive lung complications, unfortunately known: breathlessness, dyspnoea, up to severe acute respiratory syndrome and death.

Theory is the first step in any verification. Science proceeds by refutations. If this thesis were confirmed, many unknowns would be explained, for example why Covid-19 affects more men, diabetics, and less women in general, and even less pregnant women, and very few children and thalassemia. The circle would close.

But let's get into the merits of the theory. The virus needs porphyrins for its survival, probably for its replication, therefore it attacks hemogloblin (the protein that carries oxygen in the blood), in particular the OFR10 and OFR3 proteins attack the beta chain and orf1ab subtracts porphyrin. The concepts seem a little abstruse, for a non-expert, but simplifying this translates into a lower availability of oxygen available to our body, with consequent accumulation of carbon dioxide. So the lung cells become distressed and become the site of the cytokine cascade - that is, a huge immune response - responsible for the acute inflammation that characterizes Covid-19 pneumonia. The hemoglobin value in the blood can be an important parameter for evaluating Sars-Cov2 infection: in men the normal value of Hb (hemoglobin) is higher than in women, which would explain the higher incidence of Covid pneumonia in men than to women, the lower incidence and the better prognosis in children and pregnant women, where the Hb values are lower due to an increased need for iron, which makes the "nourishment" of the virus less available. In elderly or middle-aged patients with diabetes, Covid pneumonia19 has a higher incidence, therefore linked to the increase in blood glucose Hb, and therefore there is greater "nourishment" for the virus.

Viral damage, therefore, is systemic, that is, it affects the blood and is not confined only to the lung. This would also explain the birth of healthy babies from positive Covid mothers. Because in fetal Hb - stay seated, we will now use some technical concepts, but let's get back to it right away - the two beta chains are replaced by two gamma chains, a difference is the presence of a residue of serine, instead of a histidine present in the same position of the beta chain, probably responsible for binding to viral proteins, which could mimic the action of 2,3 bisphosphoglycerate. Now you can get up, let's go back to using more understandable language. All this would explain the lower incidence and the best course of the pathology in newborns, missing the main site of action of viral proteins, namely the beta chains of Hb, in short in newborns the same concept of "nourishment is lacking ”For the coronavirus.

The same goes for a chronic disease called Beta-Thalassemia, where the "beta" chains of hemoglobin (the target of the virus) are deficient or even absent. This would demonstrate the lower incidence and better prognosis and course of the pathology in beta thalassemia, which in Italy are widespread in Mediterranean areas such as Puglia, Sicily and Sardinia (in particular in the southern area) where there is an equal thalassemia rate at 12% (alpha and beta). To confirm this theory, there is a scientific publication that has linked subjects affected by beta thalassemia and Covid19, in the data taken from pubmed: as of April 10, 2020, 11 cases of positive Covid betatalaxemia have been recorded in Northern Italy, where the rate of contagiousness it is higher: 10 of them with transfusion-dependent thalassemia, the most severe form, only one with non-transfusion-dependent thalassemia.

All patients who contracted the virus, however, had concomitant, very serious diseases: splenectomized, pulmonary hypertension, lymphoma and chemotherapy. Despite this multi-pathological picture, no death, no cytokine storm or severe Sars was recorded in the 11 subjects.

Once the main mechanism of action of the virus has been revealed, many other things can be understood. For example, the central mechanism of action of hydroxychloroquine can now be explained and fully understood, and its effectiveness in countering Covid19. What this mechanism consists of is immediately said: the drug by binding permanently with ferriprotoporphyrin (of the Eme group of Hb) removes the substrate from viral proteins and also becomes an important means of prophylaxis. Although there are still no Italian publications on the effectiveness of hydroxychloroquine as a "shielding" from the virus, among the directors of the infectious disease wards, the specialists, Primaries and general practitioners contacted during this research, many admitted - under a whisper - to use the drug as a "prophylaxis", that is, to prevent infection. Healthcare professionals who are in close contact with contagious patients take the drug in advance, precisely to decrease the probability of contracting the infection. For now, in support of this "prophylaxis" effect, there is a recent publication, involving 211 people. It's been published International Journal of Antimicrobial Agents
Finally, further confirmation of this hypothesis is the data collected in the register of the SIR (Italian rheumatology society). To assess the possible correlations between chronic patients and Covid19, SIR interrogated 1,200 rheumatologists throughout Italy to collect statistics on infections. Out of an audience of 65,000 chronic patients (Lupus and Rheumatoid Arthritis), who systematically take Plaquenil / hydroxychloroquine, only 20 patients tested positive for the virus. Nobody died, nobody is in intensive care, according to the data collected so far.

 

Here is a smaller study they were also referencing @barfo

https://www.sciencedirect.com/science/article/pii/S092485792030145X?via=ihub

5. Conclusion
In this study, PEP with HCQ was implemented safely under proper monitoring and no additional patients were diagnosed with COVID-19. Randomized clinical studies are needed to evaluate whether PEP is an effective option for an outbreak response strategy against COVID-19 in LTCHs.

 

Full peer reviewed French study updated recently

https://www.mediterranee-infection....2020/03/Hydroxychloroquine_final_DOI_IJAA.pdf

1,061 Covid-19 patients

results:
“Good clinical outcome and virological cure” in 973 patients

Poor outcome for 46 patients

8 deaths (ages 74-85)

handful of side effects

 

Yes, ugh... Gotta find the damn study. It’s hard to go through the French. I’ll find it

 

https://www.mediterranee-infection....Lg7L06BYUz-8QvwuJ-hAW9uWmwx1KdKzCU0YGHtSwXXWw

https://www.mediterranee-infection....020/04/Table_final_website_IHU_09_04_2020.pdf

all I can find right now. I’ll searching for it when I’m on my computer.

 

I’m not sure there was a control group. It was just reported that it was finally peer reviewed.

 

Malaria drug touted by Trump for coronavirus fails another test
"We didn't see any association between getting this medicine and the chance of dying or being intubated," lead researcher Dr. Neil Schluger told Reuters in a telephone interview. "The patients who got the drug didn't seem to do any better."

Among patients given hydroxychloroquine, 32.3% ended up needing a ventilator or dying, compared with 14.9% of patients who were not given the drug.

But doctors were more likely to give hydroxychloroquine to sicker patients, so researchers at New York-Presbyterian Hospital and Columbia University Irving Medical Center adjusted the rates to account for that. They concluded that the drug may not have hurt patients, but it clearly did not help.

https://www.msn.com/en-us/news/us/m...or-coronavirus-fails-another-test/ar-BB13KQ4Z

 

This veteran study had peer reviewed resistance. 1.) they didn’t show the actual treatment dosage. 2.) They were on patients that we severely ill and 3.) the tables provided had major questions.

I think this was shared already btw

 

this isn't the veteran study- New England Journal of Medicine. 811 patients. is in the article i linked. edit: not randomized trials yet, was published today

 

Oh my bad, when I was reading it, I will admit I skimmed through it. Is there a link to the actual study?

 

nope not in available free articles NEJM or a link in original rueters' article.

 

Hmmm, I’ll wait until I get to see the data first. I’ll give you them the benefit for now.

 

So do women lose this protection post menopause?

 

During the early stages of post menopause women are given an estrogen substitute pill. After that they are old and expendable plus, in Trump's mind, after all, it's only women.

 

Perhaps a suicide attempt?