OT Coronavirus: America in chaos, News and Updates. 780,000 Americans dead and counting

Discussion in 'Blazers OT Forum' started by SlyPokerDog, Jan 3, 2020.

  1. barfo

    barfo triggered obsessive commie pinko Staff Member Global Moderator

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    You really can't go wrong with bbq sauce.

    barfo
     
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  2. Lanny

    Lanny Original Season Ticket Holder "Mr. Big Shot"

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    That's also where the highest crime rates are. Do you know why? Because high density areas have their criminals plus the ones from low density areas where there are fewer jobs and less money. If low density areas were to keep their problematic residents at home you'd have a lot less trouble in those big cities you refer to. By the way, Molalla has a far worse drug problem than Portland.
     
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  3. Lanny

    Lanny Original Season Ticket Holder "Mr. Big Shot"

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    What site are you referring to?
     
  4. Lanny

    Lanny Original Season Ticket Holder "Mr. Big Shot"

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    I call bullshit. Do you have a credible link supporting that bullshit?
     
  5. Orion Bailey

    Orion Bailey Well-Known Member

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    i agree. It is infuriating. But the masters behind the curtain don't change. Just the faces of politicians they buy. Big corp runs both parties and the news outlets.
    Thats why i stick to my ideals regardless of party and dont trust most politically pushed news.
     
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  6. crandc

    crandc Well-Known Member

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    How can someone say they don't trust politically pushed news when they spout it over and over? CDC, NIH not perfect but they are not politically pushed news.
     
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  7. Orion Bailey

    Orion Bailey Well-Known Member

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    Anything funded will be funded by people with agendas….
    No one said the cdc was politically pushed news. But the cdc is funded by some with special interests. and that brings skepticism to what is rolled out and accurate news and stats.

    Coming from four years of fake news by trump that so many bitch about, i would think there would be some understanding for others who have the same concern now.

    https://www.ashclinicalnews.org/online-exclusives/cdc-pressed-acknowledge-industry-funding/
     
  8. Orion Bailey

    Orion Bailey Well-Known Member

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    okay. That's such a cop out man. Only discuss what interests you..

    So anything that might prove a statement you make incorrect may not interest you so you wont discuss it, which is exactly what happened initially.
    You refused to address something that was showing inaccuracies in your post because it didn't “interest” you.

    such a cop out…

    and why i dont take anything you and some others’ posts seriously. Been this way for years.

    an honest discussion involves discussing things that may not be of interest, bUt still relevant to the topic of discussion. You pick and choose and dismiss based on your interests, nOt based on the conversation at hand. So your conversing isn't honest aNd real.


    i wont comment on anything that doesn't interest me. Well most people aren't interested in being wrong. So nice way of just dismissing all errors on your part. Because they aren't….interesting….

    What a bs excuse…
     
  9. Lanny

    Lanny Original Season Ticket Holder "Mr. Big Shot"

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    Here's the secret, Orion Bailey, present your issues of importance such that they are more likely to be interesting to the reader.
    Which reminds me, not that this pertains to you but to make it interesting to the readers in here, the number one complaint of writers about those of us who do not right professionally is the use of white space and that is to say the parsimonious use of white space.
    Pardon the use of esoteric words but I strongly believe that people should constantly be using their dictionary to expand their lexicon (vocabulary). The best way to expand a vocabulary is to hear or see it in a conversation and immediately look it up.
    I don't say all this for anyone in particular but just any reader interested in learning in general.
     
  10. barfo

    barfo triggered obsessive commie pinko Staff Member Global Moderator

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    I don't think that's accurate, but feel free to post a link and prove me wrong.

    barfo
     
  11. Phatguysrule

    Phatguysrule Well-Known Member

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    4 years of fake news doesn't make all data useless. That's what Trump's tribe would want you to think.

    When official and professional experts all verify the numbers are accurate, and the numbers are generally repeatable across many different places, that means they can be trusted as a good source of information.

    The way you catch fake news is by checking it against other legitimate sources.
     
  12. Orion Bailey

    Orion Bailey Well-Known Member

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    if you dont think its accurate, prove it wrong.
    Dude, several here have acknowledged to me privately that you just play games here…

    The proof is in half of your posts.

    Self awareness is a valuable asset.

    “Post a link proving i play games”…

    okay. Lol…

    what you believe is not a concern to me. Im not the one constantly quoting your posts put of the blue trying to call you out. Its you and your quoting my posts i respond to. I told you before if i could put you on ignore i would. The spin and games is over the top man.

    Admit taking part in something just once…

    just once…

    but that wont interest you… so…you wont. Instead you will say prove it.

    Childrens games…

    Moving on now…
     
  13. barfo

    barfo triggered obsessive commie pinko Staff Member Global Moderator

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    Well, that sounds like an important validation of your viewpoint. No doubt you feel good about that?

    Then it should be easy for you to show an example of me refusing to continue a discussion when I've been proven wrong.

    It's like rain, on your wedding day...

    Cool. Let me know if you need help loading the truck.

    barfo
     
  14. Orion Bailey

    Orion Bailey Well-Known Member

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    Yep!
    That’s right!
     
  15. SlyPokerDog

    SlyPokerDog Woof! Staff Member Administrator

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    U of T researchers create mirror-image peptides that can neutralize SARS-CoV-2
    Researchers at the University of Toronto have created chemical compounds that can neutralize SARS-CoV-2 and several of its variants.

    In a recent paper published in the Journal of Medicinal Chemistry, the researchers report the creation of D-peptides that neutralize the virus and stop infection of cultured human cells.

    Known as mirror-image peptides, the compounds have chemical properties that make them suitable for the development of low-cost antiviral therapeutics.

    “A big advantage of mirror-image peptides is their long stability and that they are relatively cheap to produce,” says Philip Kim, senior author of the study and a professor of molecular genetics and computer science at the Donnelly Centre for Cellular and Biomolecular Research at U of T’s Temerty Faculty of Medicine.

    “You could imagine them being formulated as a nasal spray to take prophylactically to prevent infection from occurring.”

    Peptides are similar to proteins in that they are composed of the same amino-acids building blocks. But they are smaller than protein molecules. They can be designed to bind virtually any molecular target and with a greater specificity than small-molecule drugs, reducing the risk of side effects. In this way, peptides are similar to antibodies but are at least 100 times cheaper to produce thanks to their small size. The combination of low cost and easy scaling of manufacturing makes peptides attractive, particularly for low-income countries.

    But there’s a caveat. In the body, peptides are rapidly degraded by the enzymes that have evolved to stamp out harmful versions produced by bacteria and other pathogens. But science has found a solution in mirror-image peptides that are resistant to degradation.

    For reasons that remain unclear, all naturally occurring amino acids exist in a left-handed configuration, as defined by the direction in which they rotate. Consequently, all proteins and peptides are also left-handed – and known as L-peptides.

    [​IMG]
    An illustration of L-peptides made from naturally occurring amino acids on the left, and their synthetic mirror-image counterparts on the right (illustration courtesy of Pedro Valiente)

    A few years ago, Kim’s team developed a computational tool for the design of so-called D-peptides that have inverse geometry. These mirror-image molecules are manufactured from synthetic D-amino acids strung together in the same way as their left-handed counterparts. Using Kim’s design method, they can be engineered to bind the same targets with undiminished specificity. The main difference is that their unusual geometry makes them resistant to enzymes in the bloodstream that break down normal L-peptides.

    The prospect of working with D-peptides is what enticed post-doctoral researcher Pedro Valiente to join Kim’s lab one year prior to the pandemic. When COVID-19 struck, he quickly realized they could apply their tool to try to make antivirals for COVID-19. By May 2020, Valiente had already created the compounds that would prove to be potent inhibitors of the virus, although it took another year to verify that they work as expected in human cells.

    Valiente designed several D-peptides that mimic the region of the virus spike that binds the ACE2 receptor on the surface of cells. He reasoned that the peptides will bind to the receptor before the virus makes contact with it – thereby preventing infection. The hypothesis was later confirmed by the experiments with cultured human cells that were carried out by collaborators at two high-security labs in South Korea.

    What’s more, the peptides worked just as well against several variants: Alpha, Beta and Gamma, which wreaked havoc over the past year after first appearing in the UK, South Africa and Brazil, respectively. Although the researchers did not investigate the Delta variant, other evidence suggests that it, too, would be susceptible to the peptide drugs, Kim says.

    “While we focused on the variants that were circulating at the time when we were doing this work, the peptides should work on Delta as well based on the similarity with its receptor binding domain,” he says.

    Valiente says the experience of working in Kim’s lab was especially gratifying as he was able to create a potential therapeutic at record speed during the first lockdown when most of the world was at a standstill.

    By the time the researchers published their findings however, several treatments had become available, including antiviral medications, antibody cocktails and vaccines. Prompted by these global advances, the team has shifted focus from COVID-19 to trying to create compounds that target all coronaviruses, including SARS and MERS, in a bid to design a universal therapeutics as a safeguard against future pandemics.

    To this end, Kim has partnered up with a Boston biotech company Decoy Therapeutics to commercialize his research.

    https://www.utoronto.ca/news/u-t-researchers-create-mirror-image-peptides-can-neutralize-sars-cov-2
     
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  16. Phatguysrule

    Phatguysrule Well-Known Member

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    Exciting stuff! Though does this mean you'd need to constantly use a nasal spray to prevent infection? How long does a spray last? Or did I miss it?
     
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  17. SlyPokerDog

    SlyPokerDog Woof! Staff Member Administrator

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    DO YOUR OWN RESEARCH SHEEPLE!
     
  18. Orion Bailey

    Orion Bailey Well-Known Member

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    and silence… lol. Typical
     
  19. crandc

    crandc Well-Known Member

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    700,000 Americans are permanently silenced. I am not laughing.
     
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  20. Orion Bailey

    Orion Bailey Well-Known Member

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    Just avoiding anything that doesn't fit ones stance.. while trying to accuse others of the same.
    Thats the funny.
     

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